Chromosomal Abnormalities in Infertile Greek Men: A Single Institution’s Experience

Chromosomal abnormalities represent a significant genetic cause of male infertility because they impair spermatogenesis. The objective the current study was to determine prevalence and distribution chromosomal in Greek men with infertility. Four hundred eighty-eight infertile (27 azoospermic, 168 oligospermia -98 mild, 57 moderate, 13 severe- 293 normospermia) undergoing In <em>Vitro </em>Fertilization (IVF) between 2016-2022 were enrolled study. Thirty-eight fertile also studied. analysis peripheral blood lymphocytes performed using standard cytogenetic techniques. 21/488 (4.3%) tested had an abnormal karyotype; (2.7%) sex chromosome 8 (1.6%) autosomal ones. No aberration detected control group. frequency alterations significantly higher azoospermic than normospermia (37% vs 4.2% 1.4% respectively, p < 0.05). Moreover, oligospermia, more common severe group (7.7%) followed by moderate (5.25%) mild (3%). results are literature. Karyotyping is suggestive especially oligospermic /azoospermic before proceeding IVF. advent high throughput sequencing technologies genome-wide association studies will contribute discovering novel promising factors involved